Advances in the application of artificial intelligence in cancer diagnosis and treatment: A systematic review
Abstract
Artificial intelligence (AI) is revolutionizing cancer diagnosis and treatment by overcoming the limitations of traditional approaches. This systematic review, based on studies published between 2020 and 2024, analyzes AI’s impact in various oncological areas, emphasizing its role in early detection, personalized treatments, and optimization of clinical processes. Through deep and machine learning algorithms, AI has proven effective in interpreting medical images, analyzing multi-omics data, and detecting biomarkers. For example, in breast cancer, a hybrid model achieved 98.06% accuracy in tissue classification, while in colorectal cancer, pre-surgical detection improved with an Area Under the Curve (AUC) of 0.832. Additionally, AI has reduced radiotherapy planning times, facilitating treatment access in developing countries. However, challenges remain, such as the lack of standardization, the need for extensive data, and ethical concerns related to privacy and equity. Despite these barriers, recent advances underline AI’s transformative potential to improve diagnostic accuracy, therapeutic efficiency, and accessibility in cancer care. This study concludes that integrating AI could redefine cancer care but requires sustained efforts to address its limitations and ensure ethical and equitable application.
References
1. Ruiz Bedolla E, Ortega IP. Cancer: Etiology, control and nutrition. Indian journal of applied research. 2024; 14(4): 1–10. doi: 10.36106/ijar/8110477
2. Karimi MR, Karimi AH, Abolmaali S, et al. Prospects and challenges of cancer systems medicine: From genes to disease networks. Briefings in Bioinformatics. 2022; 23(1): bbab343. doi: 10.1093/bib/bbab343
3. Tarale P, Naoghare P, Tagde J, et al. Diverse Cancer Therapeutic Interactions: Complexities in Cancer Management. In: Kumar M, Sharma A, Kumar P (editors). Pharmacotherapeutic Botanicals for Cancer Chemoprevention. Springer; 2020. pp. 47–66. doi: 10.1007/978-981-15-5999-0_3
4. Saraf S, De A, Tripathy BK. Effective Use of Computational Biology and Artificial Intelligence in the Domain of Medical Oncology. In: Computational Intelligence for Oncology and Neurological Disorders. CRC Press; 2024.
5. Aggarwal A, Court LE, Hoskin P, et al. ARCHERY: A prospective observational study of artificial intelligence-based radiotherapy treatment planning for cervical, head and neck and prostate cancer-study protocol. BMJ Open. 2023; 13(12). doi: 10.1136/bmjopen-2023-077253
6. Khan MS, Alshahrani MY, Wahab S, et al. Evolution of artificial intelligence as a modern technology in advanced cancer therapy. Journal of Drug Delivery Science and Technology. 2024; 98: 105892. doi: 10.1016/j.jddst.2024.105892
7. Karmakar P, Sinha S, Pal D. Artificial Intelligence. International Journal of Advanced Research in Science, Communication and Technology. 2024; 4(2): 79–87. doi: 10.48175/IJARSCT-19613
8. Shrivastava A, Pandey A, Singh N, et al. Artificial Intelligence (AI): Evolution, Methodologies, and Applications. International Journal for Research in Applied Science and Engineering Technology. 2024; 12(4): 5501–5505. doi: 10.22214/ijraset.2024.61241
9. Aliu TV. Artificial Intelligence in Special Education: A Literature Review. Systemic Analytics. 2024; 2(2). doi: 10.31181/sa22202424
10. Mian SM, Khan MS, Shawez M, and Kaur A. Artificial Intelligence (AI), Machine Learning (ML) & Deep Learning (DL): A Comprehensive Overview on Techniques, Applications and Research Directions. In: Proceedings of the 2024 2nd International Conference on Sustainable Computing and Smart Systems (ICSCSS); 10–12 July 2024; Coimbatore, India. pp. 1404–1409.
11. Wang Y. Innovative Applications of Artificial Intelligence in Specific Domains. Innovation in Science and Technology. 2024; 3(5).
12. Arefin S. IDMap: Leveraging AI and Data Technologies for Early Cancer Detection. International Journal of Scientific Research and Management (IJSRM). 2024; 12(08). doi: 10.18535/ijsrm/v12i08.mp03
13. Agrawal SK, Jain SS. Role of Artificial Intelligence in Advancing Pancreatic Cancer Research. In: Smart Healthcare Systems. CRC Press; 2024.
14. Mukherjee D, Roy D, Thakur S. Transforming Cancer Care: The Impact of AI-driven Strategies. Current Cancer Drug Targets. 2025; 25(2): 204–207.
15. Badawy W, Zinhom H, Shaban M. Navigating ethical considerations in the use of artificial intelligence for patient care: A systematic review. International Nursing Review. 2024; doi: 10.1111/inr.13059
16. Suresh NV, Selvakumar A, Sridhar G, Catherine S. Ethical Considerations in AI Implementation for Patient Data Security and Privacy. In: AI Healthcare Applications and Security, Ethical, and Legal Considerations. IGI Global Scientific Publishing; 2024. pp. 139–147. doi: 10.4018/979-8-3693-7452-8.ch008
17. Rosenbacke R, Melhus Å, McKee M, Stuckler D. How Explainable Artificial Intelligence Can Increase or Decrease Clinicians’ Trust in AI Applications in Health Care: Systematic Review. JMIR AI. 2024; 3(1): e53207. doi: 10.2196/53207
18. Wubineh BZ, Deriba FG, Woldeyohannis MM. Exploring the opportunities and challenges of implementing artificial intelligence in healthcare: A systematic literature review. Urologic Oncology: Seminars and Original Investigations. 2024; 42(3): 48–56. doi: 10.1016/j.urolonc.2023.11.019
19. Almasri IA. The Power of Artificial Intelligence for Improved Patient Outcomes, Ethical Practices and Overcoming Challenges. Igmin Research. 2024; 2(7): 585–588. doi: 10.61927/igmin222
20. Elsman EBM, Mokkink LB, Terwee CB, et al. Guideline for reporting systematic reviews of outcome measurement instruments (OMIs): PRISMA-COSMIN for OMIs 2024. Health and Quality of Life Outcomes. 2024; 22(1): 48. doi: 10.1186/s12955-024-02256-9
21. Liu W. Accuracy of funding information in Scopus: A comparative case study. Scientometrics. 2020; 124(1): 803–811. doi: 10.1007/s11192-020-03458-w
22. Vengadesh S, Chinna PR, Aravindaraj K. A Bibliometric Analysis of Research Trends in Goods Transportation Using the Scopus Database. Business Perspectives and Research. 2023. doi: 10.1177/22785337221148807
23. Wijewickrema M. Reality or Illusion: Comparing Google Scholar and Scopus Data for Predatory Journals. Libraries and the Academy. 2024; 24(1): 35–58.
24. Gusenbauer M. Beyond Google Scholar, Scopus, and Web of Science: An evaluation of the backward and forward citation coverage of 59 databases’ citation indices. Research Synthesis Methods. 2024; 15(5): 802–817. doi: 10.1002/jrsm.1729
25. Parizaca-Ninaja RM, Huamantuna-Sullo AE, Pizarro-Ninasivincha JY, Apaza JYG. Online teacher training and distance learning: Scientometrics and review in Scopus and ScIELO (Spanish). FIDES ET RATIO. 2024; 28(28). doi: 10.55739/fer.v28i28.158
26. Xu D, Chen R, Jiang Y, et al. Application of machine learning in the prediction of deficient mismatch repair in patients with colorectal cancer based on routine preoperative characterization. Frontiers in Oncology. 2022; 12. doi: 10.3389/fonc.2022.1049305
27. Pasupuleti RM, Subba Rao SPV, Kothandan P, et al. An automated detection and classification of brain tumor from MRIs using Water Chaotic Fruitfly Optimization (WChFO) based Deep Recurrent Neural Network (DRNN). IMAGING. 2023; 15(2): 73–86. doi: 10.1556/1647.2023.00122
28. Koyama J, Morise M, Furukawa T, et al. Artificial intelligence-based personalized survival prediction using clinical and radiomics features in patients with advanced non-small cell lung cancer. BMC Cancer. 2024; 24(1). doi: 10.1186/s12885-024-13190-w
29. Yin W, Huang J, Chen J, Ji Y. A study on skin tumor classification based on dense convolutional networks with fused metadata. Frontiers in Oncology. 2022; 12. doi: 10.3389/fonc.2022.989894
30. Xiao W, Liu C, Jiang K, et al. Convolutional neural network for oral cancer detection combined with improved tunicate swarm algorithm to detect oral cancer. Scientific Reports. 2024; 14(1). doi: 10.1038/s41598-024-79250-0
31. Xiao Z, Liu X, Wang Y, et al. Comprehensive analysis of single-cell and bulk RNA sequencing reveals postoperative progression markers for non-muscle invasive bladder cancer and predicts responses to immunotherapy. Discover Oncology. 2024; 15(1). doi: 10.1007/s12672-024-01548-2
32. Jia Y, Chen Y, Liu J. Prognosis-Predictive Signature and Nomogram Based on Autophagy-Related Long Non-coding RNAs for Hepatocellular Carcinoma. Frontiers in Genetics. 2020; 11. doi: 10.3389/fgene.2020.608668
33. Srinivasu PN, Jaya Lakshmi G, Gudipalli A, et al. XAI-driven CatBoost multi-layer perceptron neural network for analyzing breast cancer. Scientific Reports. 2024; 14(1): 28674. doi: 10.1038/s41598-024-79620-8
34. Weitz M, Pfeiffer JR, Patel S, et al. Performance of an AI-powered visualization software platform for precision surgery in breast cancer patients. NPJ Breast Cancer. 2024; 10(1): 98. doi: 10.1038/s41523-024-00696-6
35. RI AC, Bai VMA. Optimized Deep Convolutional Neural Network for the Prediction of Breast Cancer Recurrence. Journal of Applied Engineering and Technological Science (JAETS). 2023; 5(1). doi: 10.37385/jaets.v5i1.3384
36. Zhang Y, Cheng X, Luo X, et al. Prediction of esophageal fistula in radiotherapy/chemoradiotherapy for patients with advanced esophageal cancer by a clinical-deep learning radiomics model: Prediction of esophageal fistula in radiotherapy/chemoradiotherapy patients. BMC Medical Imaging. 2024; 24(1). doi: 10.1186/s12880-024-01473-4
37. Uzun S, Güney E, Bingöl B. Segmentation of Brain Tumor MRI Images with U-Net Architecture (Turkish). El-Cezeri Journal of Science and Engineering. 2022; 9(4): 1583–1590. doi: 10.31202/ecjse.1169424
38. Song Y, Zhang Y, Xie S, Song X. Screening and diagnosis of triple negative breast cancer based on rapid metabolic fingerprinting by conductive polymer spray ionization mass spectrometry and machine learning. Frontiers in Cell and Developmental Biology. 2022; 10: 1075810. doi: 10.3389/fcell.2022.1075810
39. Xing X, Hu E, Ouyang J, et al. Integrated omics landscape of hepatocellular carcinoma suggests proteomic subtypes for precision therapy. Cell Reports Medicine. 2023; 4(12): 101315. doi: 10.1016/j.xcrm.2023.101315
40. Liao T, Su T, Lu Y, et al. Random survival forest algorithm for risk stratification and survival prediction in gastric neuroendocrine neoplasms. Scientific Reports. 2024; 14(1): 26969. doi: 10.1038/s41598-024-77988-1
41. Qi X. Artificial intelligence-assisted magnetic resonance imaging technology in the differential diagnosis and prognosis prediction of endometrial cancer. Scientific Reports. 2024; 14(1): 26878. doi: 10.1038/s41598-024-78081-3
42. Feng J, Yu SR, Zhang YP, et al. A system based on deep convolutional neural network improves the detection of early gastric cancer. Frontiers in Oncology. 2022; 12. doi: 10.3389/fonc.2022.1021625
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