Open AccessISSN:1556-5297(print)
ISSN:1556-5300(online)
Publication Frequency: Monthly
The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications. This journal will encourage the exchange of ideas that may be seminal, or hold promise to stimulate others to new findings.
In 2024, SIN-CHN SCIENTIFIC PRESS acquired Molecular & Cellular Biomechanics from Tech Science Press, and will publish this journal from Volume 21, 2024. As of 1 March 2024, new submissions should be made to our Open Journal Systems. To view your previous submissions, please access TSP system.
After investigation, it was found that some of the manuscripts published in this journal came from a "paper mill", which has been manipulating submissions through social media account "Wechat: dr-prof-ben". The journal has now retracted all the manuscripts involved.
Read more about Retraction
Open Access
Article
Yaopeng Wang
Molecular & Cellular Biomechanics,
23(1), 671,
2026, DOI: 10.62617/mcb671
Abstract：
Multifunctional nanocomposites are developing to be productive in the co-delivery of proteins, genes and drugs due to their unique structures and properties, which holds great promise for intervening in biological processes at the cellular and molecular levels. Therefore, this thesis is based sson the application issues of drug and gene co-delivery systems, and from the application requirements, multifunctional nanocomposites CPDs/AuNCs based on carbonized polymer dots and gold nanoclusters were designed and synthesized. The specific properties of the nanomaterials were also investigated through the structural characterization, optical stability, cytotoxicity, and drug loading and releasing. The formation of the CPDs after reacting with the AuNCs The vibration of CPDs/AuNCs nanocomposites disappeared at 3250 cm−1. This transformation could potentially influence how these nanocomposites interact with cell membranes and intracellular components, altering the biomechanical forces at play during cellular uptake and trafficking. The fluorescence intensity of CPDs/AuNCs varied between [81.72,87.74] when the NaCl concentration was elevated from 0 nM to 90 mM. The emission peak of DOX at 420 nm excitation wavelength was located at around 673 nM, whereas the emission peaks of CPDs/AuNCs were located at 647 nm and 693 nm, respectively. The drug release was elevated by about 1.51-fold when the pH was decreased from 7.2 to 5.4. The multifunctional nanocomposites designed by combining CPDs with AuNCs can achieve the co-delivery of drugs and genes, and their strong optical stability also provides a new reference for real-time cell tracking. This research underscores the significance of biomechanics in optimizing cellular interactions with nanomaterials, paving the way for advancements in targeted therapies. By applying biomechanical principles, these nanocomposites can enhance drug delivery efficacy, ultimately improving therapeutic outcomes and supporting innovative approaches in personalized medicine.
Submit a Paper
