The effect of fluconazole combined with amphotericin B on highly toxic miR-15b and TGF-β1 of cronobacter in neonates
Abstract
Objective: To analyze the effects of fluconazole combined with amphotericin B on the levels of miR-15b and transforming growth factor-β1 in patients with cronobacter in neonates. Methods: Using the random number table method, twenty-eight patients who were admitted to our hospital between January 2018 and January 2021 with cronobacter pneumonia were chosen and split into two groups: the control group and the observation group. For 14 days, they received either fluconazole with amphotericin B or amphotericin B alone. The pulmonary function forced expiratory volume in one second (FEV1) and forced vital (FORCED vital) of the two groups were observed and recorded Capacity (FVC), forced expiratory volume/forced vital volume in one second/orced vital Capacity, FEV1/FVC), procalcitonin (PCT), soluble receptor expressed on myeloid (Triggering receptor expressed on myeloid) Cells-1, StreM-1), Mir-15b and TGF-β1, and the clinical efficacy was evaluated. Results: After treatment, the levels of FEV1, FVC and FEV1/FVC in patients were increased, and the levels of FEV1, FVC and FEV1/FVC in observation group were higher than those in control group (P < 0.05). After treatment, the levels of PCT and sTREM-1 were decreased, while the levels of miR-15b and TGF-β1 were increased. Compared with the control group, the levels of PCT and TREM-1 were lower in the observation group, while the levels of miR-15b and TGF-β1 were higher (P < 0.05). The total effective rate of observation group (92.86%) was significantly higher than that of control group (57.14%), the difference was statistically significant (P < 0.05). Conclusion: Fluconazole plus amphotericin B has demonstrated clinical efficacy in treating patients with cronobacter pneumonia in neonates. It can effectively improve the inflammatory state of the body, miR-15b, and TGF-β1, as well as aid in improving lung function with fewer side effects and high safety.
References
1. Jiang XQ, Zhang YB. cronobacter in neonates pneumonia in a human immunodeficiency virus-negative patient: a case report . World J Clin Cases, 2020,8(10):2038-2043.
2. Wu HH, Chen YX, Fang SY. Pleural effusion in an immunocompetent host with cronobacter in neonates pneumonia: A case report. World J Clin Cases, 2020,8(7):1295-1300.
3. Silva AP, Zenatti CT, Figueiredo-Mello C, et al. Should we perform the serum cronobacter in neonates antigen test in people living with HIV hospitalized due to a community-acquired pneumonia episode. Int J STD AIDS, 2020,31(4):345-350.
4. Huang ZW, Zhang JJ. Overview of clinical pharmacological studies of amphotericin B. Chinese Journal of Mycology, 2021,16(3):188-193,210.
5. WANG Man-Man, ZHANG Xue-Yuan, QI Huan-Huan, et al. Clinical pharmacology study of liposomal amphotericin B for injection. Chinese Journal of Infection and Chemotherapy,2021,21(3):362-368.
6. Xu Zewei, Deng Wenqiu, Liu Yanbin. Clinical study of amphotericin B combined with flucytosine and fluconazole in 45 cases of non-HIV-infected, non-organ-transplanted cronobacter in neonates meningitis. Chinese Journal of Infection and Chemotherapy,2020,20(4):396-400.
7. Wang LILIN, Li AIXIN, Yang XUE, et al. Predictors of efficacy of amphotericin B combined with fluconazole in the treatment of AIDS combined with novel cronobacter in neonates meningoencephalitis. Modern Biomedical Progress,2020,20(14):2676-2679.
8. Editorial board of Chinese Journal of Mycology. Expert consensus on the diagnosis and treatment of cronobacter in neonates infections. Chinese Journal of Mycology, 2010, 5(2): 65-68,86.
9. Groll AH, Rijnders BJA, Walsh TJ, et al. Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B. Clin Infect Dis, 2019,68(4):S260-S274.
10. Martin-Loeches I, De Waele JJ, Timsit JF, et al. Conventional amphotericin B must be avoided in Candida infections. Intensive Care Med, 2020,46(3):560-561.
11. Mou Xiangdong, Cai Cunliang, Zhao Jingquan, et al. A case of pulmonary aspergillosis treated with local instillation of amphotericin B via bronchoscopy under virtual bronchoscopic navigation. Chinese Medical Journal,2020,100(30):2391-2392.
12. Han Huanhuan. Research progress of voriconazole combined with amphotericin B in the treatment of invasive pulmonary aspergillosis. Zhongnan Pharmacology,2020,18(7):1206-1209.
13. Guo HJ, Peng CHL, Liu SX. Study of amphotericin B nebulized inhalation plus local instillation combined with voriconazole in the treatment of invasive pulmonary fungal infections. Journal of practical clinical medicine,2020,24(14):41-44.
14. Sardar, M. S., Rasheed, K., Cancan, M., Farahani, M. R., Alaeiyan, M., & Patil, S. V. Fault Tolerant Metric Dimension of Arithmetic Graphs. Journal of Combinatorial Mathematics and Combinatorial Computing, 122, 13-32.
15. Wang Danying, Yang Yunmei. Clinical analysis of 42 cases of elderly patients with pulmonary cryptococcosis. Chinese Journal of Geriatrics,2021,40(7):899-903.
16. Su YY, Zhao JP, Wang JI Miao. Current status of research related to one case of fluconazole-insusceptible Cryptococcus infection with drug resistance in vitro. Journal of Internal Medicine Acute and Critical Care,2019,25(3):249-252.
17. Guo, C. The Setting and Dynamic Adjustment Mechanism of Law Majors Facing the Development of Regional New Economy. Journal of Combinatorial Mathematics and Combinatorial Computing, 120, 43-50.
18. Zhao Q, Cheng JH, YW, et al. Clinical analysis of 47 cases of pulmonary cryptococcosis. Journal of Clinical Pulmonology,2020,25(5):668-770.
19. Zhao Zhaoyang, Su Jiao, He Ningjie, et al. Clinical analysis of 17 cases of pulmonary cryptococcosis with normal immune function. Henan Medical Research,2019,28(5):797-800.
20. Chen A-L, Zhu J-H, Chen Z-H, et al. The value of serum (1,3)-β-D-glucan combined with PCT assay in invasive fungal infections. World abstract of the latest medical information (serial electronic journal),2019,19(86):39-40,50.
21. Zhang Yongmei, He Jun, Ma Yaqing, et al. Expression of miR-127-5p, miR-3686 and sTREM-1 in alveolar lavage fluid of severe pneumonia and the relationship with disease and prognosis. Journal of Tianjin Medical University,2021,27(4):354-359.
22. Gu SH, Lin Y. Retrospective analysis of 47 cases of pulmonary cryptococcosis in immunocompetent hosts. Journal of Clinical Pulmonology,2021,26(12):1794-1799.
23. Huang Gui-Xian, Liang Shan-Shan, Peng Ying, et al. miR-125b-5p promotes the survival of Mycobacterium avium in host cells and mice. Microbiology and Infection,2020,15(2):82-87.
24. Zhou XH, Song L, Dong J. Effects of Qinglung Ba Wei Tang on serum TGF-β1 and TNF-α in post-chemotherapy tumor patients and its role in the prevention of radiation pneumonia. Cancer Progress,2017,15(6):642-644,695.
25. Hu ZW, Gu XJ, Jiang Y, et al. Efficacy of acupuncture combined with yin detoxification method in the treatment of radiation pneumonia and the effects on serum IL-6, TGF-β1 and CRP. Journal of Modern Integrative Chinese and Western Medicine,2021,30(30):3344-3348.
Copyright (c) 2024 Yafei Xu, Hui Li
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright on all articles published in this journal is retained by the author(s), while the author(s) grant the publisher as the original publisher to publish the article.
Articles published in this journal are licensed under a Creative Commons Attribution 4.0 International, which means they can be shared, adapted and distributed provided that the original published version is cited.
Submit a Paper
