Exploring heart failure treatment via calf & inner thigh electroacupuncture from cell molecular biomechanics perspective within “Three Yin Theories” framework
Abstract
Object: To guide meridian external treatment based on the “Three Yin Theories” of Water Warmth, Earth Harmony, and Wood Reaching, and to observe from a cell molecular biomechanics perspective the clinical efficacy of electroacupuncture at the calf (Chuai) and inner thigh in the treatment of heart failure. This involves analyzing how the electroacupuncture might influence cellular and molecular events within cardiomyocytes and related cardiovascular tissues. Methods: Chronic heart failure patients hospitalized in general wards were selected, and the efficacy indices before and after treatment in patients, as well as the differences between groups, were comparatively observed and studied. To explore the mechanism, not only the correlation between the reduction of neuro-endocrine hormone levels and symptom improvement was analyzed through correlation studies, but also the impact on cell molecular biomechanics was investigated. This includes examining changes in the biomechanical properties of the extracellular matrix surrounding cardiomyocytes, as well as alterations in the molecular forces and interactions that govern cell adhesion and communication within the heart tissue. Results: There was a significant difference between the treatment and control groups before and after the treatment (Sig. (two-tailed) < 0.05), and the intergroup difference was not statistically significant (Sig. (two-tailed) > 0.05), failing the significance test. There was a significant positive correlation between the decrease in aldosterone and the decrease in NYHA classification scores and BNP levels; Conclusion: Electroacupuncture at the calf and inner thigh has a better therapeutic effect on heart failure and has certain clinical promotion and application value. From a cell molecular biomechanics standpoint, the treatment appears to modulate key cellular and molecular processes within the heart, potentially providing a new avenue for understanding and enhancing the treatment of heart failure.
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