Molecular and cellular level analysis of the mechanism of nutritional intervention in preventing epidemic virus infection

  • Mingzhe Liu Nursing Department of Heze Medical College, Heze 274000, Shandong, China
  • Xia Liu School of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine (School of Life Sciences), Nanchang 330004, Jiangxi, China
Keywords: molecular; cellular level; nutrition; human body; artificial intelligence; multi-scale convolutional neural network
Article ID: 129

Abstract

Molecular nutrition encompasses a wider range of investigations than nutritional genomics, which can be considered a scientific investigation of how different nutrients and dietary components influence the cellular and molecular mechanisms of the body and health. In effect, increasing antioxidant elements in daily diets can assist with combating the inflammatory response caused by cytokines in the human body. Antioxidants can impede the oxidation process and hence avoid the creation of free radicals in the cytoplasm that can damage the cells via chain reactions. Contamination sequences, batch effects, uneven sampling, unreported taxa, technological biases, and heteroscedasticity are all significant issues in molecular microbial biology. Artificial Intelligence (AI) methodologies to uncover hidden patterns, connections, and interactions within metabolomics data, allowing them to provide personalized food recommendations based on individual health profiles. A multi-scale convolutional neural network (MCNN) classifies cellular images into phenotypes in a single coherent step utilizing the image’s pixel intensity values. Hence, the proposed AI-MCNN has been an essential nutrient that assists the immune system in various ways, including acting as an antioxidant to protect healthy cells, promoting immune cell development and function, and creating antibodies. According to epidemiological research, people who are undernourished are more likely to get bacterial, viral, and other diseases. Nutritional epidemiology investigates dietary or nutritional parameters concerning illness prevalence in communities. Nutritional epidemiology results often add to the evidence that provides dietary recommendations for preventing disease and related disorders.

References

1. Ong CWM, Migliori GB, Raviglione M, et al. Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Mycobacterial Infections (ESGMYC). European Respiratory Journal. 2020; 56(4): 2001727. doi: 10.1183/13993003.01727-2020

2. Rani I, Goyal A, Bhatnagar M, et al. Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19. Nutrition Research. 2021; 92: 109–128. doi: 10.1016/j.nutres.2021.05.008

3. Piret J, Boivin G. Viral Interference between Respiratory Viruses. Emerging Infectious Diseases. 2022; 28(2): 273–281. doi: 10.3201/eid2802.211727

4. Xia Q, Xun Y, Lu J, et al. Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19. Cell Proliferation. 2020; 53(12). doi: 10.1111/cpr.12949

5. Arun M. Experimental Investigation on Energy and Exergy Analysis of Solar Water Heating System Using Zinc Oxide-Based Nanofluid. Arabian Journal for Science and Engineering. 2022; 48(3): 3977–3988. doi: 10.1007/s13369-022-07369-1

6. Patel B, Sharma S, Nair N, et al. Therapeutic opportunities of edible antiviral plants for COVID-19. Molecular and Cellular Biochemistry. 2021; 476(6): 2345–2364. doi: 10.1007/s11010-021-04084-7

7. Huang K, Zhang P, Zhang Z, et al. Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms. Pharmacology & Therapeutics. 2021; 225: 107843. doi: 10.1016/j.pharmthera.2021.107843

8. Xu Y, Baylink DJ, Chen CS, et al. The importance of vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. Journal of Translational Medicine. 2020; 18(1). doi: 10.1186/s12967-020-02488-5

9. Azkur AK, Akdis M, Azkur D, et al. Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19. Allergy. 2020; 75(7): 1564–1581. doi: 10.1111/all.14364

10. Arun M, Barik D, Chandran SSR. Exploration of material recovery framework from waste—A revolutionary move towards clean environment. Chemical Engineering Journal Advances. 2024; 18: 100589. doi: 10.1016/j.ceja.2024.100589

11. Villena J, Kitazawa H. The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic? Frontiers in Physiology. 2020; 11. doi: 10.3389/fphys.2020.00699

12. Adusumilli NC, Zhang D, Friedman JM, et al. Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19. Nitric Oxide. 2020; 103: 4–8. doi: 10.1016/j.niox.2020.07.003

13. Astuti I. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020; 14(4): 407–412. doi: 10.1016/j.dsx.2020.04.020

14. Zhang Q, Xiang R, Huo S, et al. Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy. Signal Transduction and Targeted Therapy. 2021; 6(1). doi: 10.1038/s41392-021-00653-w

15. Xavier-Santos D, Padilha M, Fabiano GA, et al. Evidences and perspectives of the use of probiotics, prebiotics, synbiotics, and postbiotics as adjuvants for prevention and treatment of COVID-19: A bibliometric analysis and systematic review. Trends in Food Science & Technology. 2022; 120: 174–192. doi: 10.1016/j.tifs.2021.12.033

16. Alagawany M, Attia YA, Farag MR, et al. The Strategy of Boosting the Immune System Under the COVID-19 Pandemic. Frontiers in Veterinary Science. 2021; 7. doi: 10.3389/fvets.2020.570748

17. Alwazeer D, Liu FFC, Wu XY, et al. Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives. Hasnain MS, ed. Oxidative Medicine and Cellular Longevity. 2021; 2021: 1–17. doi: 10.1155/2021/5513868

18. Woods JA, Hutchinson NT, Powers SK, et al. The COVID-19 pandemic and physical activity. Sports Medicine and Health Science. 2020; 2(2): 55–64. doi: 10.1016/j.smhs.2020.05.006

19. BourBour F, Mirzaei Dahka S, Gholamalizadeh M, et al. Nutrients in prevention, treatment, and management of viral infections; special focus on Coronavirus. Archives of Physiology and Biochemistry. 2020; 129(1): 16–25. doi: 10.1080/13813455.2020.1791188

20. Messina G, Polito R, Monda V, et al. Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work. International Journal of Molecular Sciences. 2020; 21(9): 3104. doi: 10.3390/ijms21093104

21. Thirumdas R, Kothakota A, Pandiselvam R, et al. Role of food nutrients and supplementation in fighting against viral infections and boosting immunity: A review. Trends in Food Science & Technology. 2021; 110: 66–77. doi: 10.1016/j.tifs.2021.01.069

22. V’kovski P, Kratzel A, Steiner S, et al. Coronavirus biology and replication: implications for SARS-CoV-2. Nature Reviews Microbiology. 2020; 19(3): 155–170. doi: 10.1038/s41579-020-00468-6

23. Morais AHA, Passos TS, Maciel BLL, et al. Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection? Nutrients. 2020; 12(6): 1737. doi: 10.3390/nu12061737

24. Muzammil K, Hooshiar MH, Varmazyar S, et al. Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection. Microbial Cell Factories. 2024; 23(1). doi: 10.1186/s12934-024-02355-8

25. Shorobi FM, Nisa FY, Saha S, et al. Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions. Molecules. 2023; 28(3): 938. doi: 10.3390/molecules28030938

26. Starshinova AA, Kudryavtsev I, Malkova A, et al. Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection. International Journal of Molecular Sciences. 2022; 23(4): 2235. doi: 10.3390/ijms23042235

27. Available online: https://www.kaggle.com/datasets/ulrikthygepedersen/nutritional-food-facts (accessed on 20 May 2024).

Published
2024-09-03
How to Cite
Liu, M., & Liu, X. (2024). Molecular and cellular level analysis of the mechanism of nutritional intervention in preventing epidemic virus infection. Molecular & Cellular Biomechanics, 21, 129. https://doi.org/10.62617/mcb.v21.129
Section
Article