Study on cellular behavior and molecular mechanism of periodontal tissue in vitro

  • Zhaojun Tian Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  • Ting Chen Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
Keywords: periodontal regeneration; human periodontal ligament cells (PDLCs); human bone marrow derived mesenchymal stem cells (hMSCs); osteogenic differentiation; tissue engineering; Wnt/β-catenin signaling pathway; in vitro proliferation
Article ID: 1263

Abstract

Periodontal regeneration is the ultimate goal of periodontal therapy. In the study of constructing periodontal tissue in vitro, attempts are made to simulate the regeneration process of periodontal tissue. The research and clinical application of periodontal ligament stem cells have made many breakthroughs, but they still face many challenges. To achieve true periodontal tissue regeneration, in-depth research on its molecular mechanism and signaling pathway is still needed. Combined with the research progress in recent years, this paper discusses the challenges and possible solutions faced in the process of periodontal tissue regeneration.

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Published
2025-03-04
How to Cite
Tian, Z., & Chen, T. (2025). Study on cellular behavior and molecular mechanism of periodontal tissue in vitro. Molecular & Cellular Biomechanics, 22(4), 1263. https://doi.org/10.62617/mcb1263
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Article