Molecular regulation mechanism of inflammatory cytokines in cerebrospinal fluid exosomes in the progression of multiple sclerosis

  • Jie Li Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China; First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China; Xiangya Hospital of Central South University Jiangxi Hospital, Nanchang 330006, China
  • Ting Chen Comprehensive Breast Health Center, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Yanhong Chen Department of Intensive Medicine, Jiangxi Province Cancer Hospital, Nanchang 330006, China
  • Wangwang Hong Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China; First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China; Xiangya Hospital of Central South University Jiangxi Hospital, Nanchang 330006, China
  • Hong Zhang Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China; First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China; Xiangya Hospital of Central South University Jiangxi Hospital, Nanchang 330006, China
  • Xiaoqing Lu Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China; First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China; Xiangya Hospital of Central South University Jiangxi Hospital, Nanchang 330006, China
DOI: https://doi.org/10.62617/mcb1092
Keywords: cerebrospinal fluid exosomes; inflammatory cytokines; multiple sclerosis; molecular regulatory mechanisms; neuroinflammationt
Article ID: 1092

Abstract

Extracellular vesicles (EVs), which are small vesicles secreted by various cells, have been proven to play a significant role in the progression of multiple diseases, including multiple sclerosis (MS). This study explores the potential regulatory mechanisms of EVs in MS progression and their role as carriers of cytokines such as TNF-α and IL-6. Through numerical simulations and experimental methods, we investigated the impact of EVs and their cytokine cargo concentrations on immune responses and neuroinflammation. The results from numerical simulations indicate that EVs not only serve as carriers for cytokines but also modulate inflammatory responses through interactions with immune cells, thereby influencing the pathological process of MS. Experimental data further validate the role of pro-inflammatory cytokines carried by EVs in enhancing immune activation and promoting neuroinjury. These findings suggest that EVs may be important mediators in regulating immune responses and could potentially become new targets for MS therapy.

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Published
2025-03-10
How to Cite
Li, J., Chen, T., Chen, Y., Hong, W., Zhang, H., & Lu, X. (2025). Molecular regulation mechanism of inflammatory cytokines in cerebrospinal fluid exosomes in the progression of multiple sclerosis. Molecular & Cellular Biomechanics, 22(4), 1092. https://doi.org/10.62617/mcb1092
Issue
Vol. 22 No. 4 (2025)
Section
Article

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