Deadline for manuscript submissions:16 September,2025

 

Special Issue Editors

 Prof. Tiancheng Xu Website   E-Mail: xtc@njucm.edu.cn
Guest Editor
Nanjing University of Chinese Medicine
Interests: Insulin resistance; obesity; T2DM

 

Special Issue Information

 

The biological mechanisms underlying glycolipid metabolic disorders represent a cutting-edge frontier in contemporary medical research. These disorders, which include diabetes, obesity, and related metabolic syndromes, are characterized by dysregulation in glucose and lipid metabolism, leading to severe health complications such as cardiovascular diseases, insulin resistance, and non-alcoholic fatty liver disease. At the cellular level, the interplay between insulin signaling pathways, mitochondrial dysfunction, and endoplasmic reticulum stress is critical in understanding the pathogenesis of these conditions. Recent advancements in molecular biology and omics technologies have unveiled intricate networks of gene expression, protein interactions, and metabolic fluxes that contribute to the development and progression of glycolipid metabolic disorders.

 

Current research is particularly focused on the role of autophagy, inflammation, and gut microbiota in modulating metabolic homeostasis. For instance, impaired autophagy has been linked to the accumulation of damaged organelles and lipid droplets, exacerbating metabolic stress. Additionally, chronic low-grade inflammation, driven by adipocyte dysfunction and immune cell infiltration, is now recognized as a key player in insulin resistance. The gut microbiome, through its influence on host metabolism and immune responses, further complicates the metabolic landscape. Understanding these cellular mechanisms not only provides insights into disease etiology but also opens avenues for novel therapeutic strategies, making this field a vibrant and essential area of investigation.

 

Keywords:

• Glycolipid Metabolic Disorders  
• Insulin Resistance  
• Cellular Mechanisms
• Autophagy
• Gut Microbiota

 

 

 

 

Published Papers