Deadline for manuscript submissions: 31 January 2025

 

Special Issue Editors

Prof. Dr. Lingfeng Zeng  Website  E-Mail: lingfengzeng@gzucm.edu.cn
Guest Editor
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou University of Chinese Medicine, China
Interests: bone and cartilage diseases; metabolomics; ethnopharmacology; bone aging and osteoporosis; plant-based natural products; medicinal plants; phytochemicals; traditional Chinese medicine; evidence-based medicine

Prof. Dr. Claudio Lucchiari  Website  E-Mail: claudio.lucchiari@unimi.it
Guest Editor
University of Milan, Italy
Interests: metabolism and plant nutrition; diseases risk prediction and risk assessment; disease scale characteristics evaluation and psychological assessment; health education and management; the development of health products; et al.

 

Special Issue Information

Dear colleagues,

Cellular senescence refers to a process induced by various types of stress that causes irreversible cell cycle arrest and distinct cellular alterations, including profound changes in gene expression, metabolism, and chromatin organization as well as activation/ reinforcement of anti-apoptotic pathways and development of a pro-inflammatory secretome or senescence-associated secretory phenotype (SASP). New findings indicated that senescent cells and their SASP may play a vital role in the development of musculoskeletal system diseases, such as osteoarthritis (OA), osteoporosis (OP), or osteonecrosis of the femoral head (ONFH), et al. The underlying mechanism may be the accumulation of senescent cells or their SASP at sites of pathology or old tissues. And some encouraging results find Seno-therapeutics by targeting senescent cells or inhibiting some specific SASP, such as IL-6, TNF-a, et al, could provide benefits for cartilage regeneration or bone remodeling in preclinical models. While a number of scientific issues need to be uncovered, such as the crosstalk between senescent and their neighborhood healthy cells, the main cell type that becomes senescent in the development and pathology of bone and cartilage, and the link between senescent cells and local or system immune system.

The goal of this research topic is to provide a forum for advancing research on the contribution of cellular senescence to the development and pathology of bone and cartilage, as well as to explore innovative seno-therapeutics in an attempt to provide new treatment options for musculoskeletal disease.

In this research topic, we welcome the submission of Original Research, Review, Mini Review, Clinical Trial, Perspective, and Opinion articles, focusing on but not limited to the following topics:
- The new preclinical or clinical evidence of the role of cellular senescence in OA or OP;
- The interplay between senescence cells and local or system immune cells, such as macrophage, or T cells;
- The internal relationship between aging, immunity, and inflammation;
- We also welcome evidence-based research on plant-based natural products.

Prof. Dr. Lingfeng Zeng
Prof. Dr. Claudio Lucchiari
Guest Editors

 

Keywords

cellular senescence
musculoskeletal system disease
SASP
inflammation
seno-therapeutics
evidence-based medicine
medicinal activity
ethnopharmacology

 

Published Papers