Deadline for manuscript submissions: 30 June 2025

 

Special Issue Editors

Dr. Diego A. Bonilla Website  E-Mail: dabonilla@dbss.pro
Guest Editor
1 Research Division, Dynamical Business & Science Society – DBSS International SAS, Colombia
2 Hologenomiks Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Spain
Interests: active researcher in molecular sciences applied to exercise, health, and disease; interested in studying adaptation processes using in silico methods and wet lab technologies

Dr. Jorge L. Petro Website  E-Mail: jlpetros@dbss.pro
Guest Editor
1 Research Division, Dynamical Business & Science Society – DBSS International SAS, Colombia
2 Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, Colombia
Interests: physiology; molecular and cellular biology; exercise physiology; physiology of nutrition; exercise and health

 

Special Issue Information

Dear colleagues,

 

The concept of exercise and cell physiology is so intimately related that, in its very essence, it forms the basis of human health and performance. Thus, exercise biochemistry and physiology are focused on the study of those molecular and cellular processes that are responsible for energy metabolism in key tissues like skeletal muscle as well as function and adaptation to physical stress. Supporting the increasing energy demand during exercise, there is activation of complex biochemical pathways leading to profound changes within the muscle cell: the activation of ATP production, oxidative phosphorylation, and substrate utilization. These processes are finely tuned by a variety of signaling molecules, hormones, and enzymes whose activation is dynamically sensitive to intensity and duration of exercise. Cellular adaptation, at the level of muscle function, mitochondrial functions and behaviors, and tissue repair, is provoked by exercise.

 

Interaction among cellular systems-skeletal muscle, adipose tissue, and the cardiovascular system-will provide an explanation of how exercise enhances metabolic health via reduced inflammation and diminishes the risk for chronic diseases. The interplay among exercise stress responses and gene expression regulation has also been informative regarding the roles of physical activity in both long-term health and athletic performance. Integrating exercise physiology, genomics, and cellular biology, this issue presents a holistic view of molecular processes governing performance and adaptation. This special issue aims to outline recent research regarding the biochemical and physiological mechanisms underlying exercise, focusing mainly on metabolic regulation, cellular signaling, and muscle plasticity.

 

Using state-of-the-art analytical techniques, such as omics and systems biology, this will aim to further detail the molecular bases underpinning exercise and underline how this information can be used to inform training and health strategies. It, therefore, avails an opportunity for the revisiting and further refinement of some of the critical concepts in exercise science that may require revisiting for the advancement of the field itself and to help bridge the gap between traditional understandings and contemporary scientific findings. We hereby invite colleagues from around the world to submit original articles, experimental mechanistic studies, epidemiological studies, and systematic reviews with meta-analyses.

 

Dr. Diego A. Bonilla

Dr. Jorge L. Petro

Guest Editors

 

Keywords

• physiological stress response
• exercise biochemistry
• cellular physiology
• exercise physiology
• allostatic load and overload
• allostasis and stress-related energy expenditure
• systems biology
• physiological circuits
• individual and population adaptive responses
• acute and chronic effects of exercise
• sex-based differences on the adaptation process
• exercise as medicine

 

Published Papers